Dr. Jeffrey Gladden’s foremost ambition is to help people live well beyond 100 years. That goal also entails assuring that individuals who live to be 120 or 130 years keep active and in tiptop shape — both physically and mentally.

“Being in shape is being fast, agile, strong, quick, balanced, flexible with great cardiovascular endurance and good recovery,” he explains. “If you’re going to have that later in life, you’ve got to focus on all of those things.” His medical program, Gladden Longevity, is engaged in working to realize those ambitions.

“We currently have a research protocol that’s in play for people to participate in, where that’s literally what we’re going for,” he says. “What we’re really going for is making 100 the new 30.”

While his program has therapies and devices that he says can help people achieve those objectives (though they can be costly), individuals can take direct action themselves to conquer the aging process. Rather than acquiescing to the traditional idea that aging means slowing down and losing impact, they can reject that belief and keep moving positively forward. Good sleep and eating habits, and remaining physically active, can contribute to that upward arc.

“If you’re asking questions,” he says, “that’s growth. If you’re stuck with your answers, that’s decline, quite honestly. Having a growth mindset is critical.”

Dr. Gladden’s strategy involves four interlacing “circles” -  health, longevity, performance and life energy. He says people should approach these concepts exponentially rather than from a linear perspective. ***** Dr. Jeffrey Gladden is the founder, medical director and CEO of Gladden Longevity, a Texas-based concierge medical program established to optimize individuals’ health and prolong their lives. Clients are given customized treatment plans configured to their own individual situations.

Dr. Gladden segued into his work in age management medicine, functional medicine and integrative medicine from his earlier career as a cardiologist — at least in part because he had witnessed his own healthy body and mind begin to slide downhill as he moved through middle age. d feel myself go over this cliff of depression.” He received a bachelor of science degree in chemistry from Wheaton College in 1976. He went on to earn a doctor of medicine degree from Temple University Medical School in 1982 and a degree in internal medicine from Case Western Reserve University of Medicine in 1985. From 1985 through 1988 Dr. Gladden was part of the Interventional Cardiology Fellowship Program at the University of Colorado.

Besides his work at Gladden Longevity, he has spent the past decade as board chair, CEO and chief medical officer for product development at Scientia Cardio Access, a medical start-up in Salt Lake City that develops therapies and devices for medical interventional specialists.

He also has been, for the past 27 years, the CEO and president of Advanced Heart Care, a preventive diagnostic and interventional  cardiology practice in Texas. 

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Dr. Richard Restak concurs with the 18th century British writer, Samuel Johnson, who once said, “The true art of memory is the art of attention.”A neurologist and neuropsychologist and expert on the human brain, Dr. Restak believes that all methods of nourishing and protecting one’s memory entail the ability to focus attention. His favorite technique is turning words into visual images to establish what he calls a “memory path.”“Seeing something and converting the word or a sense into a picture, into a mental drawing, is the key to setting up memory,” he explains.Dr. Restak also advocates other paths for protecting one’s memory - cooking (which can require organization and memorization of recipes), the use of technology (to support memory, not replace it), getting adequate sleep, playing games, avoiding fast food and trending toward vegetarianism, and exercising. Guest Bio:Dr. Richard Restak is a noted neurologist and neuropsychiatrist who has written extensively on the subject of the human brain.He is the author of 20 books, all on aspects of the brain, two of which were New York Times Best Sellers - The Brain (1984) and The Mind (1988). Both those books were turned into television series by the Public Broadcasting System.His most recent book, The Complete Guide to Memory: The Science of Strengthening Your Mind, published in 2021, is a cornucopia of information on memory and offers numerous suggestions for how individuals can enhance their memory and protect it from deteriorating.Dr. Restak earned degrees from Gettysburg College and Georgetown University School of Medicine. He completed his internship at St. Vincent’s Hospital in New York City and residencies at Georgetown University Hospital and George Washington University Hospital. Now 80, he still has a private practice in  neurology and neuropsychology and is a clinical professor of neurology at George Washington Hospital University School of Medicine and Health.Often appearing as a guest on television and radio shows, Dr. Restak has written articles for numerous newspapers and contributed entries on neuroscience and the brain to the Encyclopedia Brittanica and the Encyclopedia of Neuroscience.

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The Salk Institute’s Cellular Neurobiology Laboratory, which Pamela Maher, PhD heads, has been studying CBN. It is a chemical found in marijuana and findings show how it can protect nerve cells in the brain from oxidative damage, a major pathway to cell death. Their research also suggests that CBN works to protect the brain’s mitochondria. Mitochondria is called the powerhouse of a cell. 

Pair these two findings and the neuroprotective benefits CBN produces might be helpful in preventing diseases like Alzheimer’s and Parkinson’s, Maher says. However, human clinical trials are still years away. The lab’s research thus far involves only mice.

CBN is molecularly similar to THC, but is not psychoactive. Because it won’t get one high, it is legal in every state. CBN is already produced commercially, sometimes in pill form, gummies or tinctures. Evidence suggests it is safe in animals and humans. 

Dr. Pamela Maher, a neuroscientist, is a research professor at the Salk Institute and the head of Salk’s Cellular Neurobiology Laboratory. A senior staff scientist at Salk since 2004, she has concentrated her research on screening for compounds that can halt the progress of neurodegenerative brain disorders, including Alzheimer’s disease.

Dr. Maher's website: https://www.salk.edu/scientist/pamela-maher/

Maher earned her undergraduate degree in Biochemistry from McGill University in Montreal, a PhD in Biochemistry from the University of British Columbia in Vancouver, and a Postdoc in Cell Biology from the University of California, San Diego.

In 1979 she was granted a Killam Predoctoral Fellowship, in 1980 an Anna Fuller Postdoctoral Fellowship, and in 1982 an NIH Postdoctoral Fellowship.

Dr. Maher has been the recipient of several major awards, including the Michael J. Fox Foundation Award for Novel Approaches to Drug Discovery for Parkinson’s Disease in 2007 and the Edward N. And Della L. Thome Memorial Foundation Award in Alzheimer’s Disease Drug Discovery in 2015.

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