Read the full transcript here: https://cuttingedgehealth.com/wp-content/uploads/2024/03/Transcript-35-Cutting-Edge-Health-with-David-Haase.pdf

In this episode of the "Cutting Edge Health Preventing Cognitive Decline" podcast, Jane Rogers introduces David Haase, MD, a pioneering doctor in the field of cognitive decline treatment and the “coach” of the #1-ranked Rejuvenation Olympian.

Dr. Haase’s approach centers on therapeutic plasma exchange, a process aimed at removing harmful proteins and molecules from the blood, which are associated with deteriorating brain function. Haase received his medical degree from Vanderbilt University School of Medicine and did his residency at the Mayo Clinic. Today he is based in Nashville, Tennessee, at his Maxwell Clinic. Dr. Haase has spent over two decades working towards improving brain health and functionality through integrative and innovative treatments.

Dr. Haase discusses the efficacy of therapeutic plasma exchange in reversing dementia and cognitive decline, citing the AMBAR study, which showed significant improvements in Alzheimer's patients. This treatment, according to Dr. Haase, is a breakthrough yet remains underutilized due to a lack of awareness and financial backing. The procedure involves replacing a patient's plasma with a clean albumin solution, which can lead to improvements in cognitive functions and a reduction in neurodegeneration markers. Dr. Haase emphasizes the importance of addressing cognitive health proactively, leveraging multifactorial treatments to tackle the complex causation of cognitive decline.

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David Haase, MD is a Vanderbilt, Mayo Clinic, double board certified , VERY CURIOUS physician.

In 2003 Dr. Haase founded the MaxWell Clinic in Nashville, Tennessee as a living laboratory to explore the question "What Creates Health?" and he has been incessantly innovating in the fields of nutrition, genomics, mitochondrial function, systems biology, apheresis, stem-cell programming, and brain optimization ever since. His patients are those who desire the deepest personalization of innovative performance and longevity care possible.

He is the author of Curiosity Heals The Human: Solving the ‘Unsolvable’ with BetterQuestions and Advanced Technologies.

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Cutting Edge Health podcast website: https://cuttingedgehealth.com/

Cutting Edge Health Social and YouTube: YouTube channel: youtube.com/@cuttingedgehealthpodcast

Instagram - https://instagram.com/cuttingedgehealthpodcast Facebook - https://www.facebook.com/Cutting-Edge-Health-Podcast-with-Jane-Rogers-101036902255756

Please note that the information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Cutting Edge Health podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to Alan and Maria on the Cutting Edge Health team!

The interview with Dr. Yoshi Rahm on the Cutting Edge Health podcast covers topics on enhancing cognitive health. Dr. Rahm discusses his personal journey influenced by his family's health issues and his integration of holistic practices into medicine. He delves into Extracorporeal Blood Oxygenation and Ozonation (EBOO) therapy for immune system boosting and reducing inflammation. Additionally, Dr. Rahm explains the use of methylene blue for cognitive improvement, its safe dosage, and potential side effects. He emphasizes the importance of lifestyle modifications, including diet, exercise, and community for overall cognitive health. The concept of structured water and its benefits for body energy and hydration is also discussed.

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Dr. Yoshi Rahm finds meaning and joy in ever learning to be present with himself and whomever he is with in the moment, especially with his family, friends, and patients.  Much of his life's pursuits stem from growing up far outside of a small town in Northern California.  His simple upbringing, which included living without electricity, TV, or phone, gave him an early appreciation for healthy living.  The suffering of unwell family members was a big driver for Dr. Rahm to pursue healing in the form of becoming a family physician. 

After residency at Glendale Adventist Medical center, where he received the two highest distinctions: “Resident Teacher Award” as presented by the faculty and “Resident of the Year Award” as recognized by the staff, Dr. Rahm then went on to become an Attending Physician teaching at the same residency program and also founded Oasis Family Medicine. 

With the support of incredible team members at Oasis Family Medicine, they are able to serve people from around the globe who have a wide variety of medical conditions in a compassionate and effective manner, combining the best of allopathic western medicine in conjunction with an integrative and holistic healing approach.  He thrives on learning and then using that learning to teach others how to be their own greatest healers.

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Cutting Edge Health podcast website: https://cuttingedgehealth.com/

Cutting Edge Health Social and YouTube: YouTube channel: youtube.com/@cuttingedgehealthpodcast

Instagram - https://instagram.com/cuttingedgehealthpodcast Facebook - https://www.facebook.com/Cutting-Edge-Health-Podcast-with-Jane-Rogers-101036902255756

Please note that the information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Cutting Edge Health podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to Alan and Maria on the Cutting Edge Health team!

In this podcast interview, Dr. Lisa Barnes discusses her work in cognitive neuropsychology and efforts to diversify Alzheimer’s disease research by including Black Americans. With a background from the University of Michigan and UC Davis, Dr. Barnes joined Rush Medical College in 1999 and has been leading the Minority Aging Research Study since 2004, focusing on brain health within the Black community.

Dr. Barnes initiated the Minority Aging Research Study to address the underrepresentation of Black individuals in dementia research, overcoming trust barriers rooted in historical mistreatment and increasing awareness about Alzheimer’s in the Black community. The study includes over 800 participants and promotes understanding of Alzheimer’s by offering community-based education and recruitment, advocating for brain donation, and examining the link between discrimination and cognitive health. Dr. Barnes highlights the complexity of Alzheimer’s disease, noting that social determinants play a significant role in brain health and discussing genetic findings that challenge assumptions about the disease’s prevalence in Black Americans. Although some research suggests that there may be twice the incidence of Alzheimers in Black communities, Dr. Barnes notes that when studies follow people over time, there doesn’t appear to be any faster rate of decline in Black people than White people. You would expect to see a faster rate of decline if there’s more Alzheimer’s. “People thought Alzheimer’s disease is a White person’s disease, or they thought we’re supposed to lose our memory when we get older. There’s nothing you can do about it. I think we have to debunk some of those myths,” she says.

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Lisa L. Barnes, PhD is the Alla V. and Solomon Jesmer Professor of Gerontology and Geriatric Medicine and a cognitive neuropsychologist within the Rush Alzheimer’s Disease Center at Rush University Medical Center. She is also the Associate Director of the Rush Alzheimer’s Disease Research Center. She received her PhD from the University of Michigan in biopsychology and completed a postdoctoral fellowship in cognitive neuroscience at the University of California, Davis. She has been a faculty member at Rush Medical College since 1999. Dr. Barnes has received many NIH grants and has published over 300 manuscripts. Her research interests include disparities in chronic diseases of aging, cognitive decline, and risk factors for Alzheimer’s disease. She is the Principal Investigator of the Minority Aging Research Study (MARS), which has been funded by NIA since 2004, and the Clinical Core Leader for the Rush African American Clinical Core. She advocates for recruitment of under-represented groups into clinical studies and has received many awards and fellowships.

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Cutting Edge Health podcast website: https://cuttingedgehealth.com/

Cutting Edge Health Social and YouTube: YouTube channel: youtube.com/@cuttingedgehealthpodcast Instagram - https://instagram.com/cuttingedgehealthpodcast Facebook - https://www.facebook.com/Cutting-Edge-Health-Podcast-with-Jane-Rogers-101036902255756

Please note that the information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Cutting Edge Health podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to Alan and Maria on the Cutting Edge Health team!

For those who want to truly assess your genetic risk of Alzheimer’s, IntellxxDNA has created a tool to help.  With a simple cheek swab, this Austin, Texas based firm can provide you and your health care provider with a personalized genetic report that goes much deeper than what you’ll get from most genetic testing. For those with the APOE-4 Alzheimer’s gene there are other genes to know about that either can dramatically increase or decrease your risk of developing the disease.  Having this information allows one to take action early to prevent its onset.

Sharon Hausman-Cohen, MD is our guest for this podcast episode. She and her co-founder, Carol Bilich, developed IntellxxDNA. Their research is focused on making genetics actionable and understandable for each individual patient and their provider.

There are dozens of gene variants that can interact with ApoE4 and act as gene modifiers that decrease or increase ApoE4 dementia risk. Some of these include:

• TOMM40 and ApoC1 - If no TOMM40 or ApoC1, the risk of ApoE4 is lowered to very close or equal to ApoE 3/3.

• BCHE–K variant - This variant, when present, makes it more likely for amyloid to form tangles.   Only about 35% of people have this variant. Being part of the 65% of individuals who do not have this variant or being "BCHE-K variant" negative halves the risk of ApoE4. Conversely, being BCHE - K variant positive doubles the risk.

•There are other variants in detox pathways, hormone receptor pathways and inflammatory pathways and more that also interact with ApoE4. 

Listen to learn more.

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Dr. Sharon Hausman-Cohen is the Chief Medical Officer and co-founder of IntellxxDNA™.  She received both her master’s degree and medical degree from Harvard Medical School. She is a fellow of the American Academy of Family Medicine and a diplomate of the American Board of Integrative Medicine. Dr. Hausman-Cohen has been in the field of integrative medicine for over 25 years. She is the co-author of many publications relating to genomics including three that focus on cognitive decline and two that focus on autism.  She is also the primary author of a precision medicine textbook chapter on genomics and neurodegenerative diseases and a chapter in a book published by Frontiers in Neuroscience and Aging relating to frontiers in dementia treatment.  She and her co-founder developed IntellxxDNA as an answer to an unmet need in the medicine community; the need for an accurate, evidence-based genomics tool geared at helping physicians practice personalized medicine.

They envisioned and created a tool that could help identify root causes of cognitive decline, autism, environmentally acquired illness, and common chronic illnesses such as heart disease, diabetes, depression, anxiety and obesity.  IntellxxDNA’s research has focused on making genomics actionable and understandable, so that clinicians know how to address these genomic factors in a precision way. IntellxxDNA is being used as part of 3 IRB approved clinical trials relating to helping individuals with memory concerns and early dementia as well as children with autism and other complex illnesses.  It is also being used as part of medical decision-making by physicians across the country.

Dr. Hausman-Cohen loves combining her passion for science and medicine and using her scientific mind to integrate large amounts of complex data. She also enjoys teaching and has taught extensively across the country at conferences for physicians as well as for community members. Dr. Hausman-Cohen is the co-founder of Resilient Health which is her patient facing practice in Austin, TX.

For access to publications, podcasts and videos see:  IntellxxDNA.com

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Cutting Edge Health podcast website: https://cuttingedgehealth.com/

Cutting Edge Health Social and YouTube: YouTube channel: youtube.com/@cuttingedgehealthpodcast

Instagram - https://instagram.com/cuttingedgehealthpodcast Facebook - https://www.facebook.com/Cutting-Edge-Health-Podcast-with-Jane-Rogers-101036902255756

Please note that the information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Cutting Edge Health podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to Alan and Maria on the Cutting Edge Health team!

Research at Boston University has led to the discovery of a non-invasive method to diagnose Alzheimer's.  This opens the door in the coming years to possibly detecting the disease in its early stages, decades before real symptoms appear. 

Manju Subramanian, MD and her team found that proteins in eye fluids are providing this window to the brain. These eye fluids are confirming pathological brain conditions like dementia in the Alzheimer's form. Until now, MRIs and lumbar punctures were the tools to aid the clinical diagnosis of Alzheimer's, but that has meant late detection when the disease is already in place. Alzheimer's is not actually confirmed until after death and a post-mortem examination of the brain is done. 

"We know that patients with eye disease tend to be an at-risk population for dementia. Patients with macular degeneration, glaucoma and diabetic retinopathy, those are the three big ones," says Subramanian.

The potential of an eye fluid exam at an optometrist's office is ideal as it's non-invasive and not expensive.  But, it is still several years out before potentially becoming commonplace.  More research is needed. Still to be determined in future research is just how early eye fluid proteins become abnormal when dementia is developing.  

"As they say, the eye is the window to the soul.  It is also very much the window to the brain," says Subramanian.

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Manju Subramanian is an Associate Professor in Ophthalmology and Vice-Chairman of Faculty Affairs. She is an ophthalmic surgeon specializing in Vitreoretinal Disease and Surgery, and is in academic practice at Boston Medical Center. She also sees patients at the Dedham Ophthalmic Consultants. Her primary areas of clinical interest include medical and surgical management of diabetic retinopathy, age-related macular degeneration, retinal detachments, hereditary retinal diseases, ocular inflammation, and ocular trauma. Dr. Subramanian graduated from the University of Missouri School of Medicine and completed her residency at the University of Kansas Medical Center in 2002. She completed a fellowship in Vitreoretinal Disease and Surgery at Tufts University School of Medicine and Ophthalmic Consultants of Boston in 2004.

Dr. Subramanian’s research interests include the study of eye-based biomarkers for Alzheimer’s Disease (AD), age-related macular degeneration, diabetic retinopathy, and the role of anesthesia in eye surgery. She was Principal Investigator for the first head to head clinical trial comparing the use of bevacizumab and ranibizumab in the treatment of age-related macular degeneration, and she is currently the Principal Investigator for a study assessing the role of oral sedation in eye surgery. She is also a recent recipient of an R03 Grant Award by the National Institutes of Aging as the Principal Investigator of a study looking at protein biomarkers for AD in the eye.

In her role as Vice-Chairman of Faculty Affairs at Boston University Eye Associates, she works in a supportive role in the professional and career development and engagement of the clinical faculty. Prior to 2017, she served as the Vice-Chairman of Clinical Services for 8 years. She serves on several institutional committees, including the Women’s Leadership Advisory Council, the Boston University Medical Group (BUMG) Research Committee, the BU School of Medicine Promotion Criteria Working Group, and also serves as Chair of the BUMG Professional Development Committee. She additionally serves on national committees, such as the International Meetings Committee for the American Academy of Ophthalmology (AAO), the Diversity Initiatives Committee for the Association for Research in Vision and Ophthalmology (ARVO), and a Special Emphasis Panel for a Study Section with the National Institutes of Health.

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Cutting Edge Health podcast website: https://cuttingedgehealth.com/

Cutting Edge Health Social and YouTube: YouTube channel: youtube.com/@cuttingedgehealthpodcast Instagram - https://instagram.com/cuttingedgehealthpodcast Facebook - https://www.facebook.com/Cutting-Edge-Health-Podcast-with-Jane-Rogers-101036902255756

Please note that the information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Cutting Edge Health podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to Alan, Maria, Louis, and Nicole on the Cutting Edge Health team!

Dementia can be prevented, and Kat Toups, MD knows this firsthand.  Dr. Toups is a San Francisco Bay Area psychiatrist, but she is also an accomplished researcher who led investigations in 20 extensive clinical trials focused on Alzheimer's and MCI (Mild Cognitive Impairment). While working in this area, she developed dementia herself, and by using functional medicine, she reversed her own decline. 

Dr. Toups thrives on helping people. She partnered with Dale Bredesen, MD on a clinical trial using functional medicine, often called precision medicine, where 84% of the study patients with MCI and early dementia had improvements as shown on their MRI brain scans and other cognitive assessments. The study’s results were published in the Journal of Alzheimer's Disease in August 2022:  Precision Medicine Approach to Alzheimer’s Disease: Successful Pilot Project.

Following this success, Dr. Toups has now launched a much larger clinical trial in six cities around the United States. Participants must live within an hour’s drive of one of these locations:

Walnut Creek (San Francisco East Bay), CA

San Rafael (San Francisco/Marin County), CA

Sacramento (El Dorado Hills), CA

Miami (Hollywood), Florida

Nashville (Brentwood), Tennessee

Cleveland (Rocky River), Ohio

For more information: www.dementiareversaltrial.com

Dr. Toups says dementia happens for multiple reasons. It doesn’t just come out of nowhere, but likely has been slowly building for more than a decade.  Dr. Toups says it’s critical to search for contributing factors at the earliest opportunity if you want success in stopping or reversing disease progression. In this interview, she elaborates on the importance of partnering with a functional medicine doctor to do this work.  Some of the core contributors to cognitive problems might be inflammatory load in the body, heart health, hormone levels, exercise, stress, sleep, toxins, and infections amongst many other factors.

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Kat Toups, M.D., DFAPA, IFMCP is a functional medicine psychiatrist at Bay Area Wellness in Walnut Creek, CA. Dr. Toups is a distinguished fellow of the American Psychiatric Association (the highest honor bestowed by the APA), board certified by the American Board of Psychiatry and Neurology, and previously boarded in geriatric psychiatry.

Dr. Toups is a former assistant professor of psychiatry at UC Davis, where she was the inpatient residency training director, and later the owner/medical director of Bay Area Research Institute, a clinical trials research center in Lafayette, CA. After serving as the principal investigator on over 100 clinical trials for 12 years, including 20 failed trials for Alzheimer's drugs, she realized that the elusive cure for brain and psychiatric illness was not going to be found in a pill.

She embarked on an intensive course of study (initially sparked by a quest to heal her own serious autoimmune disease) to learn functional and nutritional medicine and completed her training for the Institute for Functional Medicine Certification in October 2013.

Dr. Toups practices functional medicine psychiatry, which seeks to discover the underlying causes of inflammation (like diet/nutrition, lifestyle, genetics including MTHF/Methylation/Sulfation/Detoxigenomic genetic polymorphisms, GI health including food allergies and dysbiosis, toxin exposure, chronic infections, and biochemical abnormalities) that can all be contributors to problems with psychiatric symptoms and/or cognition difficulties. Detection and correction of these problems can result in the resolution of the psychiatric symptoms, rather than just providing a band-aid by only prescribing psychiatric medications without addressing the underlying causes of the problem.

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Cutting Edge Health podcast website: https://cuttingedgehealth.com/

Cutting Edge Health Social and YouTube: YouTube channel: youtube.com/@cuttingedgehealthpodcast Instagram - https://instagram.com/cuttingedgehealthpodcast Facebook - https://www.facebook.com/Cutting-Edge-Health-Podcast-with-Jane-Rogers-101036902255756

Please note that the information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Cutting Edge Health podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to Alan, Maria, Louis, and Nicole on the Cutting Edge Health team!