Navigators, mutated by spice into beings far superior to normal humans, make space travel possible across the burgeoning Imperium. Their prescient awareness allows them to foresee safe paths through the universe as starship engines 'fold' space. Only industrial magnate Josef Venport knows the secret of creating Navigators, and he intends to build a commercial empire to span the galaxy. 

The universal computer mind Omnius has retreated to its last stronghold, where it plots a devastating new strategy that could undo the victories of the Butlerian Jihad. The surviving Titans are creating new lieutenants to do their will when at last they return to attack the human beings they once ruled. In the years of peace too many of mankind have forgotten that their machine enemies never sleep. But some have forgotten nothing - and learned from their triumphs.

Gilbertus Albans has founded the Mentat School, a place where humans can learn the efficient techniques of thinking machines. But Gilbertus walks an uneasy line between his own convictions and compromises in order to survive the Butlerian fanatics, led by the madman Manford Torondo and his Swordmaster Anari Idaho. Mother Superior Raquella attempts to rebuild her Sisterhood School on Wallach IX, with her most talented and ambitious student, Valya Harkonnen...who also has another goal - to exact revenge on Vorian Atreides.

Lady Jessica, mother of Paul and consort to Leto Atreides, is torn from her home and her family. Her choices will shape an empire, but first the Lady of Caladan must reckon with her own betrayal of the Bene Gesserit. Refusing to become a pawn, she must decide if her loyalty to the Sisterhood is more important than the love of her own family.

Tales of Dune collects eight of Herbert and Anderson’s Dune short stories, ranging from the period of the Butlerian Jihad to the time of young Paul Atreides to a story set during the events of the novel Dune to the very end of Frank Herbert’s future history.