Claudia Muldoon and her sister, Jenny, live with their parents and their gran in her house in Blodwen Street. Both parents have good jobs and the family assume they are settled for life, but then Grandpa Muldoon has a seizure and begs his son to return to Ireland. In Ireland the Muldoons flourish and the girls love the freedom of their new life, though as they grow up, disadvantages become clear. Claudia has to find work, so both sisters return to Liverpool and to their old pal Danny, who welcomes them back with delight.

One wild night in the 1930s, midwife Patty Peel is called to attend a birth on the opposite side of Liverpool. She pedals off into the storm and delivers a baby girl in a filthy slum dwelling, just as the mother dies. The drunk and violent father tells Patty to get rid of it so she takes the child away, meaning to deliver it to the nearest orphanage. However, Patty spent her entire childhood in an institution, except for the frequent occasions when she ran away, and cannot bear to hand the baby over. 

Miranda Lovage and her mother have a blazing row when Arabella tells her daughter that she can no longer afford their present lifestyle. Miranda goes to bed angry and upset. When she awakes next morning, however, it is to find that her mother has disappeared. Miranda raises the alarm but everyone is baffled, and when searches fail to discover Arabella's whereabouts, Miranda is forced to live with her Aunt Vi and cousin Beth, who resent her presence and treat her badly.

When Daisy's family lose their croft on the Connemara coast, her Aunt Jane, housekeeper to Dr. and Mrs Venables, offers to take Daisy back to Liverpool.

It's 1938, and Cadi is chosen to be Rose Queen in the annual Rose Fete. She is thrilled to be treated like royalty for the day. But deep down she is desperate to leave the Welsh mining community where she grew up. When war is declared, Cadi and her best friend, Poppy, see a chance to escape. Cadi leaves behind her parents and local boy Aled, whom she is meant to marry, for Liverpool.

Dana and Caitlin meet on the ferry from Ireland, both in search of new lives in Liverpool, having left their secrets behind in Ireland. But Dana is ambitious, and when the opportunity comes to own their own tearoom she persuades her friend to join her. No one is willing to rent property to a couple of girls, so when Caitlin’s new man-friend says he’ll back them, they are delighted. Soon the tearoom is thriving.

Imogen, Rita and Debby all missed the original evacuation and now the authorities are finding it difficult to place them. When Auntie and her niece, Jill, who run the Canary and Linnet Public House, offer to take them in, the billeting officer is greatly relieved. The countryside is heaven to the three little townies, especially after they meet Woody and Josh. They find that by climbing to the top of a tree they are able to watch the comings and goings of the young fighter pilots.

Laura Collins is struggling to make a good life for her daughters, Tess and Tina. So when she is offered a good job, with accommodation, she is delighted. Life is very different for the Brewsters who live on Manor Farm in Herefordshire. Danny plans to marry one day so that he can take over the farm, whilst his cousin, Phil, longs to escape the world of farming as soon as possible. War changes all their plans.

Nell Whitaker is 15 when war breaks out and her mother sends her to live with her Auntie Kath in a remote farmhouse on Anglesey. At first Nell hates it, but her friendship with Bryn, who works on the farm whilst waiting for his call-up papers, helps a lot. So when he leaves to join his ship, Nell is counting the days to his return. But her heart is broken when news reaches her that Bryn’s ship has been bombed and he has been drowned. Determined to bury her grief in hard work, Nell finds herself growing closer to Auntie Kath.

Addy and Prue Fairweather live with their widowed mother Nell, in a flat above her shop. Addy is plain and always in trouble whereas Prue is as angelic as her looks imply. To make matters worse, Nell makes no secret of her preference for the younger girl, increasing Addy's jealousy. On the other side of the coin, Giles Frobisher and his twin sister, Gillian, live in a crumbling mansion in Devon. The family have lost most of their money in the Depression, so Giles joins the Fleet Air Arm.

1901. Tina Rose is the beloved daughter of a wealthy Jewish family while Edward grew up with an abusive father in the wilds of New Zealand. Despite their differences, the two fall madly in love when Edward arrives in England, looking for a better future. However, the consequences of their love affair are terrible for Tina, as she is shamed by the father she adores, and Edward is sent away. Against all the odds, Tina and Edward find each other again.

Rose McAllister is waiting for her husband, Steve, to come home. He is a seaman, often drunk and violent. Rose does her best to cope and sees that her daughters, Daisy and Petal, suffer as little as possible. Sensing that war is on the horizon, Steve tries to reform, but on his last night home, he pawns the girls' new dolls to go on a drinking binge. When war is declared, Rose finds a good job but agrees the children must be evacuated. War brings hardship and difficulty for the girls and Rose as they face the destruction of their home and cruelty at the hands of others....  

Lizzie is an orphan living with her aunt Annie, uncle Perce and two boy cousins within a stone's throw of the Leeds and Liverpool Canal. Lizzie loves her aunt but is hated by her uncle. She makes friends with Geoff Gardiner, another orphan, and is teaching him to swim in the Scaldy when Clem Gilligan rescues the pair of them from drowning. Clem works on the canal boat, The Liverpool Rose, with Jake Pridmore and his wife, plying between the great cities of Leeds and Liverpool. Lizzie's situation at home starts to worsen and eventually she is forced to flee. Her first instinct is to make for the canal, but finding Clem is not so easy....

When Dot McCann, playing with her pals, decides to hide in Butcher Rathbone's almost empty dustbin, she overhears a conversation which could send one man to prison and the other to the gallows - and suddenly finds herself in possession of stolen goods. Dot lives with her aunt and uncle, abandoned after her parents died. She feels very alone until she meets up with Corky, who has run away from a London orphanage. They join forces with Emma, whose jeweller's shop has been burgled, and Nick, a young reporter who is investigating the crime.

Liverpool, 1935. Kathy Kelling is coming home to Daisy Street from her first day at the High School, longing to tell her friend, Jane, all about it. The Kellings' life becomes a struggle when Kathy’s brother, Billy, has a serious accident. He needs constant attention, and Mrs Kelling must take in lodgers so that Kathy’s schooling does not suffer. When war breaks out, Kathy and Jane are forced to grow up fast. Kathy meets the handsome Alec Hewitt, but he is more attracted to blonde, bubbly Jane. But Fate has not yet finished with Kathy Kelling....